Dieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine system

Exposure to Antineoplastic Agents Induces Cytotoxicity in Nurse Lymphocytes: Role of Mitochondrial Damage and Oxidative Stress

Cytotoxicity and mitochondrial parameters were studied in isolated lymphocytes and their mitochondria obtained from occupationally exposed nurses through inhalation exposure to antineoplastic drugs and results were compared to those of unexposed nurses. The group of occupationally exposed nurses consisted of 50 individuals ranging in age from 30 to 35 years. The control group included 50 nurses...

Exposure to Antineoplastic Agents Induces Cytotoxicity in Nurse Lymphocytes: Role of Mitochondrial Damage and Oxidative Stress

Cytotoxicity and mitochondrial parameters were studied in isolated lymphocytes and their mitochondria obtained from occupationally exposed nurses through inhalation exposure to antineoplastic drugs and results were compared to those of unexposed nurses. The group of occupationally exposed nurses consisted of 50 individuals ranging in age from 30 to 35 years. The control group included 50 nurses...

Time Course of Recovery of Extracellular Dopamine Damage to the Nigrostriatal Dopamine System following Partial

Partial damage to the nigrostriatal dopamine (DA) system can produce severe behavioral deficits, from which animals gradually recover. Although the compensatory neuroadaptations that contribute to recovery of function have received considerable attention, the exact role of presynaptic versus postsynaptic contributions remains unclear. For example, it has been suggested that presynaptic adaptati...

Disruption of dopamine transport by DDT and its metabolites.

Epidemiological studies suggest a link between pesticide exposure and an increased risk of developing Parkinson's disease (PD). Although studies have been unable to clearly identify specific pesticides that contribute to PD, a few human studies have reported higher levels of the organochlorine pesticides dieldrin and DDE (a metabolite of DDT) in post-mortem PD brains. Previously, we found that ...

Controls for lesions of the nigrostriatal dopamine system.